In the Laboratory of Molecular Medicine research is carried out on the cellular and genetic mechanisms related to the musculoskeletal system. In particular, it studies the organization of the sarcoplasmic reticulum and its relationship with the contractile apparatus, the mechanisms of action connected to the proteins involved in the release of calcium from the sarcoplasmic reticulum, the proteins connected to the cytoskeletal myofibrils (e.g. costameric proteins such as dystrophin). In addition, the genetic mutations responsible for the structural and functional organisation of skeletal muscle fibers, which are involved in genetic diseases (e.g. malignant hyperthermia, central core diseases and new forms of muscular myopathy and muscular dystrophy), are investigated.
